We will send a summary of the trial results to participants and their GPs at the end of the trial. The trial results will be also available on this website.
Can I join this study?
Yes, potentially, if you:
have received a written invitation from the ASCEND PLUS study team
are aged 55 years or above
have type 2 diabetes mellitus.
If you have a history of any of the following, you are not able to join the trial:
previous heart attack or stroke
current or planned treatment with oral semaglutide or similar type of drug: Semaglutide injections (Ozempic ® or Wegovy ®); Dulaglutide (Trulicity ®); Exenatide (Byetta ®); Liraglutide (Victoza ® or Saxenda®); Lixisenatide (Lyxumia ®)
previous allergy or intolerance to oral semaglutide or similar type of drug
low blood sugar (a ‘hypo’) for which you have needed help from another person (e.g. if you had to go to A&E or needed emergency treatment from a paramedic, friend or relative) in the last 6 months
low blood sugar (a ‘hypo’) causing symptoms in the past month
are in the process of starting insulin treatment
current or planned kidney dialysis
severe heart failure with difficulty breathing at rest
type 1 diabetes or other types of diabetes (e.g. Mature Onset Diabetes of the Young, MODY)
ongoing treatment for cancer, or a diagnosis of cancer within the last two years (some skin cancers do not affect ability to join the trial)
current or planned pregnancy or currently breastfeeding
a particular type of thyroid cancer called medullary thyroid cancer – if you have been diagnosed with thyroid cancer you can speak to a study doctor to check whether you could join the trial
any serious medical condition which is likely to make it difficult for you to take part
current participation in a clinical trial which is testing an unlicensed medication for diabetes.