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ASCEND PLUS is coordinated and sponsored by the University of Oxford, and run with support from the National Institute for Health and Care Research. NHS research staff from across the UK are helping to run the study.

Novo Nordisk produces oral semaglutide and is providing the treatment for the study free of charge. Novo Nordisk has given a grant to the University of Oxford to help with the cost of running of the study but is not directly involved with either coordinating the study or analysing the results.