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If you join the study, you will be asked to take one study tablet each day for about five years in addition to any other medications that you usually take. You will also be asked to complete a questionnaire four times in the first six months, and then once every six months. In total, this will be about 12 questionnaires spread over five years. You can choose whether you complete the questionnaires online yourself or with a research nurse by telephone or video call.

No additional clinic visits or travel are required to take part. Everything happens in your own home, and the study medication will be posted to your address. The first questionnaire takes about 30-40 minutes to complete. Subsequent questionnaires take about 20 minutes each.

During the five-year scheduled treatment period, and for up to 20 years after that, we will collect health data about you from NHS England, other NHS organisations and national registries (unless you contact us to opt out).