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During the study, participants are asked to continue their usual diabetes therapy and any other medication prescribed by you or other doctors. If it is necessary to commence a GLP-1 receptor agonist as part of your patient’s usual diabetes treatment, then the ASCEND PLUS team should be informed and the randomised study treatment will be discontinued. You patient will continue the trial follow-up procedures.

  • ASCEND PLUS (A Study of Cardiovascular Events iN Diabetes PLUS) is a randomised double-blind placebo-controlled trial sponsored by the University of Oxford.
  • ASCEND PLUS is registered with clinicaltrials.gov (NCT05441267) and ISRCTN (ISRCTN76193287).
  • The UTN universal trial number for ASCEND PLUS is U1111-1284-0262.
  • Protocol [PDF]